Noey2 gene compositions and methods of use

Details Noey2 gene compositions and methods of use Noey2 gene compositions and methods of use

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 7/00 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2284685

Disclosed are compositions and methods comprising a novel tumor suppressor gene, designated NOEY2, that is expressed in normal ovarian and breast surface epithelial cells but consistently absent or down-regulated in ovarian and breast cancer cells. Disclosed are polynucleotide compositions comprising a NOEY2 gene from mammalian sources, and polypeptides encoded by these nucleic acid sequences. Also disclosed are methods for preparing NOEY2 polypeptides, transformed host cells, and antibodies reactive with NOEY2 polypeptides. In certain embodiments, the invention describes methods for diagnosing and treating cancers, as well as methods for identifying NOEY2-related polynucleotide and polypeptide compositions.

L'invention porte sur des compositions et méthodes utilisant un nouveau gène suppresseur de tumeurs, le NOEY2 qui est exprimé par les cellules épithéliales superficielles saines des ovaires et du sein, mais régulièrement absent ou sous-produit dans les cellules cancéreuses des ovaires et du sein. L'invention porte également sur des compositions de polynucléotides comprenant un gène NOEY2 provenant de mammifères et sur des polypeptides codés par ces séquences d'acide nucléique. L'invention porte en outre sur des procédés de préparation des polypeptides NOEY2, des cellules hôtes transformées, et des anticorps réagissant avec les polypeptides NOEY2. Dans certaines de ses réalisions, l'invention porte sur des méthodes de diagnostic et de traitement du cancer, et des méthodes d'identification des compositions de polynucléotides et de polypeptides apparentés au NOEY2.

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