C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/12 (2006.01)
Patent
CA 2523022
The present invention relates to previously unknown biological roles of Nogo- B. We have discovered that Nogo-B is a component of endothelial cells. We have also discovered that Nogo-B is highly expressed in intact blood vessels. The amino terminus of Nogo-B promotes the adhesion, spreading and migration of endothelial cells and plays a role in vascular remodeling. Thus, Nogo-B is a novel regulator of vascular homeostasis and remodeling. The present invention provides compositions comprising Nogo-B and fragments and fusion proteins thereof. The present invention also relates to nucleic acids encoding Nogo-B and fragments and fusion proteins thereof, as well as vectors and cells comprising such nucleic acids. The present invention also relates to antibodies specific for Nogo-B and fragments and fusion proteins thereof. The present invention also provides methods for preventing, detecting and treating Nogo-B-related diseases, disorders and conditions.
L'invention concerne les rôles biologiques, inconnus jusqu'ici, de Nogo-B. On a découvert que Nogo-B est un composant des cellules endothéliales et qu'il est exprimé à un degré élevé dans les vaisseaux sanguins intacts. La terminaison amino de Nogo-B stimule l'adhésion, l'étalement et la migration des cellules endothéliales et joue un rôle dans le remodelage vasculaire. Par conséquent, Nogo-B est un nouveau régulateur de l'homéostase et du remodelage vasculaire. L'invention concerne également : des compositions qui comprennent Nogo-B ainsi que des fragments et des protéines de fusion de celui-ci ; des acides nucléiques codant pour Nogo-B et les protéines de fusion de celui-ci ainsi que des vecteurs et des cellules comprenant lesdits acides nucléiques ; des anticorps spécifiques de Nogo-B et des fragments et des protéines de fusion de celui-ci ; des méthodes de prévention, de détection et de traitement de maladies, de troubles et d'affections associés à Nogo-B.
Acevedo Lisette
Sessa William C.
Acevedo Lisette
Sessa William C.
Smart & Biggar
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