Nogo receptor antagonists

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/705 (2006.01) C12N 5/0793 (2010.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61P 25/00 (2006.01) C07K 16/28 (2006.01) C12N 15/12 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2495121

Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen~binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same.

L'invention concerne des polypeptides de récepteurs-1 Nogo immunogéniques, des anticorps de récepteurs-1 Nogo, des fragments de liaison à l'antigène de ceux-ci, des récepteurs Nogo solubles et des protéines de fusion de ceux-ci, ainsi que des acides nucléiques les codant. L'invention concerne également des compositions comprenant de tels anticorps de récepteurs Nogo, de tels fragments de liaison à l'antigène de ceux-ci, de tels récepteurs Nogo solubles et de telles protéines de fusion de ceux-ci, ainsi que des acides nucléiques les codant. L'invention concerne enfin des procédés destinés à produire et à utiliser ces composés.

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