Nogo receptor binding small molecules to promote axonal growth

G - Physics – 01 – N

Patent

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G01N 33/566 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2707076

The present invention provides a method for identifying compounds which modulate the interaction of Nogo and Nogo receptor (NgR). The present invention also provides compounds that modulate the interaction of Nogo and Nogo receptor (NgR), the use of such compounds and compositions in the treatment or amelioration of conditions diseases or disorders, such as spinal cord injury, traumatic brain injury, stroke, multiple sclerosis, ALS, Huntington's disease, Alzheimer's disease, Parkinson's disease, epilepsy, Schizophrenia or schizoaffective disorders.

La présente invention concerne un procédé d'identification de composés qui modulent l'interaction de Nogo et du récepteur Nogo (NgR). La présente invention concerne également des composés qui modulent l'interaction de Nogo et du récepteur Nogo (NgR), l'utilisation de tels composés et compositions dans le traitement ou l'amélioration d'états, maladies ou troubles, tels qu'une blessure de la moelle épinière, une lésion cérébrale traumatique, un accident cérébrovasculaire, une sclérose en plaques, une SLA, la maladie d'Huntington, la maladie d'Alzheimer, la maladie de Parkinson, l'épilepsie, la schizophrénie ou des troubles schizoaffectifs.

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