Nogo receptor homologs

Details Nogo receptor homologs Nogo receptor homologs

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/62 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2424834

The invention relates generally to genes that encode proteins that inhibit axonal growth. The invention relates specifically to genes encodign NgR protein homologs in humans and mice. The invention also includes compositions and methods for modulating the expression and activity of Nogo and the NgR proteins. Specifically, the invention includes peptides, proteins and antibodies that block Nogo-mediated inhibition of axonal extension. The compositions and methods of the invention are useful in the treatment of cranial o cerebral trauma, sprial cord injury, stroke or a demyelinating disease.

Cette invention, qui a trait, d'une manière générale, à des gènes codant des protéines inhibant la croissance des axones, concerne, plus précisément, des gènes codant des homologues de la protéine NgR chez des humains et des souris. Elle porte, de plus, sur des compositions, ainsi que sur les procédés afférents, permettant de moduler l'expression et l'activité de Nogo et celles des protéines NgR. Elle concerne, notamment, des peptides, des protéines ainsi que des anticorps bloquant l'inhibition liée à Nogo d'une extension des axones. Ces compositions, ainsi que les procédés afférents, se révèlent des plus utiles en matière de traitement de trauma crânien ou cérébral, de lésion médullaire, d'accident cérébro-vasculaire ou de trouble de démyélinisation.

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