Non-a, non-b, hepatitis virus particles

Details Non-a, non-b, hepatitis virus particles Non-a, non-b, hepatitis virus particles

C - Chemistry, Metallurgy

12

N

C12N 7/01 (2006.01) A61K 39/29 (2006.01) C07K 14/18 (2006.01) C12N 1/21 (2006.01) C12N 15/51 (2006.01) G01N 33/576 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2045326

ABSTRACT OF THE DISCLOSURE Disclosed are an isolated non-A, non-B hepatitis virus particle comprising at least one antigen selected from the group consisting of a core antigen, a matrix antigen and an envelope antigen of the non-A, non-B hepatitis virus and a method for efficiently producing the same by genetic engi- neering. The non-A, non-B hepatitis virus particle can advantageously be used not only for the production of an NANBV hepatitis vaccine exhibiting an extremely high immu- nogenicity and a diagnostic reagent which is extremely high in the antibody detection ratio and in the degree of accu- racy of the detection, but is also useful for researches on liver diseases, such as liver cancer.

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