C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/033 (2006.01) C07K 14/435 (2006.01) C07K 16/18 (2006.01) C12N 15/10 (2006.01) C12P 19/34 (2006.01) C12P 21/02 (2006.01) G01N 33/58 (2006.01)
Patent
CA 2434737
Nucleic acid compositions encoding non-aggregating chromo/fluoroproteins and mutants thereof, as well as the proteins encoded by the same, are provided. The proteins of interest are polypeptides that are non-aggregating colored and/or fluorescent proteins, where the the non-aggregating feature arises from the modulation of residues in the N-terminus of the protein and the chromo and/or fluorescent feature arises from the interaction of two or more residues of the protein. Also provided are fragments of the subject nucleic acids and the peptides encoded thereby, as well as antibodies to the subject proteins and transgenic cells and organisms. The subject protein and nucleic acid compositions find use in a variety of different applications. Finally, kits for use in such applications, e.g., that include the subject nucleic acid compositions, are provided.
L'invention concerne des compositions à base d'acides nucléiques codant des chromo/fluoroprotéines anti-agrégantes et des gènes mutants associés, ainsi que des protéines codées par ceux-ci. Ces protéines sont des polypeptides composés de protéines anti-agrégantes colorées et/ou fluorescentes, dans lesquelles la caractéristique d'anti-agrégation résulte de la modulation des résidus N-terminal de la protéine, et la caractéristique de coloration et/ou de fluorescence découle de l'interaction entre deux résidus ou plus de la protéine. Par ailleurs, l'invention concerne des fragments des acides nucléiques précités et des peptides codés par ceux-ci, ainsi que des anticorps dirigées contre les protéines, cellules et organismes transgéniques en question. On peut utiliser les compositions à base de protéines et d'acides nucléiques précitées dans diverses applications différentes. L'invention concerne enfin des kits destinés à ces applications, contenant par exemple les compositions d'acides nucléiques susmentionnées.
Fradkov Arcady
Lukyanov Konstantin
Lukyanov Sergey
Savitsky Alexandr
Yanushevich Yuriy
Clontech Laboratories Inc.
Smart & Biggar
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