C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 37/06 (2006.01) C07K 16/28 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12N 15/86 (2006.01) C12N 15/861 (2006.01) C12N 15/867 (2006.01)
Patent
CA 2410188
The present invention is directed to antibodies which bind human gp39, are antagonistic of the CD40/CD40L interaction, but are non-agonistic of T-cell activation. The present invention is futher directed to the use of these antibodies as therapeutic agents. These antibodies are especially useful for treatment of autoimmune diseases; and an immunosuppressant during transplantation of heterologous cells, tissues or organs, cell therapy, and gene therapy.
L'invention concerne des anticorps qui lient la gp39 humaine, qui sont des antagonistes de l'interaction CD40/CD40L, mais qui ne sont pas des non agonistiques de l'activation de lymphocytes T. L'invention concerne en outre l'utilisation de ces anticorps comme agents thérapeutiques. Ces anticorps sont particulièrement utiles pour traiter des maladies auto-immunes; et comme immunosuppresseurs lors de transplantations de cellules, de tissus ou d'organes hétérologues, et lors de thérapies cellulaire et génique.
Anderson Darrell R.
Hanna Nabil
Kloetzer William S.
Pan Li Zhen
Rastetter William H.
Biogen Idec Inc.
Idec Pharmaceutical Corporation
Smart & Biggar
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