C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/20 (2006.01) A61K 31/4184 (2006.01) A61K 31/437 (2006.01) A61P 25/06 (2006.01) C07D 235/02 (2006.01) C07D 471/10 (2006.01)
Patent
CA 2734334
The present invention is directed to novel non-amidic linkers with branched termini derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
La présente invention porte sur de nouveaux lieurs non amidiques avec des dérivés terminaux ramifiés, qui sont des antagonistes de récepteurs de peptides associés au gène de la calcitonine (CGRP), et qui sont utiles dans le traitement ou la prévention de maladies dans lesquelles les peptides associés au gène de la calcitonine entrent en jeu, telles que la migraine. L'invention porte également sur des compositions pharmaceutiques renfermant ces composés et sur l'utilisation de ces composés et compositions dans la prévention ou le traitement des maladies dans lesquelles les peptides associés au gène de la calcitonine entrent en jeu.
Kim June J.
Selnick Harold G.
Stachel Shawn J.
Wood Michael R.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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