C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 31/519 (2006.01) A61P 7/00 (2006.01) C07D 209/08 (2006.01) C07D 209/12 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2402516
The present invention provides novel compounds of the Formula (I) its prodrug forms, or pharmaceutically acceptable salts thereof. Preferred compounds of the present invention comprise a pyrrolo pyridinyl, pyrrolo pyrimidinyl or indole nucleus. The compounds of this invention are inhibitors of Factor Xa (FXa), Factor VIIa (FVIIa) and/or serine proteases, Urokinase (uPA), and have utility as anti-coagulants for the treatment or prevention of thromboembolic disorders in mammals and as anticancer agents.
La présente invention concerne de nouveaux composés de la formule (I), leurs promédicaments ou sels pharmaceutiquement acceptables. Des composés préférés de l'invention comprennent un pyrrolo pyridinyle, un pyrrolo pyrimidinyle ou un noyau indole. Les composés de l'invention sont des inhibiteurs du facteur Xa (FXa), du factor VIIa (FVIIa) et/ou de la sérine protéase, de l'urokinase (uPA), et sont utiles comme anti-coagulants destinés au traitement ou à la prévention de troubles thromboemboliques chez les mammifères, ou comme agents anticancéreux.
Kolesnikov Aleksandr
Rai Roopa
Axys Pharmaceuticals
Fetherstonhaugh & Co.
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