Non-anaphylactic forms of grass pollen ph1 p 6 allergen and...

Details Non-anaphylactic forms of grass pollen ph1 p 6 allergen and... Non-anaphylactic forms of grass pollen ph1 p 6 allergen and...

C - Chemistry, Metallurgy

07

K

C07K 14/415 (2006.01) A61K 39/36 (2006.01) A61P 37/08 (2006.01) A61K 38/11 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2387260

The invention relates to a hypoallergenic immunogenic molecule derived from the Phl p 6 allergen, wherein the Phl p 6 molecule has an N-terminal and/or C- terminal deletion which makes the molecule at least substantially lack IgE binding capacity. The invention also relates to a hypoallergenic immunogenic combination of molecules derived from the Phl p 6 allergen, comprising: (i) a Phl p 6 molecule having an N-terminal deletion which makes the molecule at least substantially lack IgE binding capacity, and (ii) a Phl p 6 molecule having a C-terminal deletion which makes the molecule at least substantially lack IgE binding capacity, which two molecules together encompass the complete sequence of Phl p 6. The invention further relates to the use of the hypoallergenic immunogenic molecule or molecule mixture in hyposensitization and diagnosis.

L'invention concerne une molécule immunogène hypoallergénique dérivée de l'allergène Phl p 6, où la molécule Phl p 6 présente une délétion du N terminal et/ou du C terminal, ce qui fait que la molécule manque au moins sensiblement de capacité de liaison IgE. L'invention concerne également une combinaison immunogène hypoallergénique de molécules dérivées de l'allergène Phl p 6, comprenant (i) une molécule Phl p 6 ayant une délétion du N terminal de sorte que la molécule manque au moins sensiblement de capacité de liaison IgE, et (ii) une molécule Phl p 6 ayant une délétion du C terminal de sorte que la molécule manque au moins sensiblement de capacité de liaison IgE, les deux molécules renfermant la séquence complète de Phl p 6. L'invention concerne également l'utilisation de la molécule, ou du mélange de molécules, immunogène hypoallergénique dans l'hyposensibilisation et le diagnostic.

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