C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 275/03 (2006.01) A61K 31/425 (2006.01) A61K 31/427 (2006.01) A61K 31/4427 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 25/28 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2594404
The present invention relates to certain novel compounds of the formula (I) to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X Receptor (LXR) .alpha. (NR1H3) and/or .beta. (NR1H2) and in treating and/or preventing clinical conditions including cardiovascular diseases such as atherosclerosis; inflammatory diseases, Alzheimer's disease, lipid disorders (dyslipidemias) whether or not associated with insulin resistance, type 2 diabetes and other manifestations of the metabolic syndrome, to methods for their therapeutic use and to pharmaceutical compositions containing them.
L'invention concerne de nouveaux composés de formule (I) et des procédés pour préparer de tels composés. L'invention concerne également l'utilisation de tels composés pour moduler des récepteurs hormonaux nucléaires hépatiques (LXR) .alpha. (NR1H3) et/ou .beta. (NR1H2) et pour traiter et/ou pour prévenir des troubles cliniques, notamment des maladies cardio-vasculaires, comme l'athérosclérose; des maladies inflammatoires, la maladie d'Alzheimer, des troubles lipidiques (dyslipidémies) associés ou pas à une résistance à l'insuline, des diabètes de type II et d'autres manifestations du syndrome métabolique. L'invention concerne encore des méthodes pour l'utilisation thérapeutique de ces composés et des compositions pharmaceutiques contenant ces composés.
Brickmann Kay
Broo Anders
Holm Patrik
Judkins Robert
Li Lanna
Astrazeneca Ab
Fetherstonhaugh & Co.
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