Non-anticoagulant chemically modified heparinoids for...

C - Chemistry – Metallurgy – 08 – B

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C08B 37/00 (2006.01) A61K 31/725 (1995.01)

Patent

CA 2158052

A method of treating hypovolemic shock and related shock syndromes by the administration of substantially non-anticoagulant heparinoids without the hemorrhaging problems generally associated with heparin is disclosed. Such syndromes include degradation of the microvascular structure, immune and gastrointestinal tract dysfunction, and multiple organ failure. The figure shows changes in mean arterial pressure (MAP) and heart rate (HR) in sham- operated, normal saline-treated, heparin-treated, and 2-0-desulfated non- anticoagulant-heparin-treated rats after the initiation of crystalloid resuscitation.

Méthode de traitement des chocs hypovolémiques et des syndromes associés par administration de d'héparinoïdes sensiblement non anticoagulants éliminant les problèmes d'hémorragie liés à l'héparine. Ces syndromes comprennent la dégradation de la structure microvasculaire, les troubles immunitaires et des voies digestives ainsi que les défaillances touchant plusieurs organes. La figure illustre des variations de la tension artérielle moyenne et du rythme cardiaque chez des rats soumis à des opérations fictives traités à la solution physiologique, à l'héparine, et à l'héparine non anticoagulante 2-O-désulfatée après le début de la réanimation par cristalloïde.

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