Non-antigenic branched polymer conjugates

C - Chemistry – Metallurgy – 08 – G

Patent

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Details

C08G 63/91 (2006.01) A61K 39/00 (2006.01) A61K 47/48 (2006.01) C08G 65/329 (2006.01) C08G 65/332 (2006.01) C08G 65/333 (2006.01) C08L 89/00 (2006.01)

Patent

CA 2283939

Branched, substantially non-antigenic polymers are disclosed. Conjugates prepared with the polymers and biologically active molecules such as proteins and peptides demonstrate extended circulating life in vivo. Substantially fewer sites on the biologically active material are used as attachment sites. Methods of forming the polymer, conjugating the polymers with biologically active moieties and methods of using the conjugates are also disclosed.

Cette invention se rapporte à des polymères ramifiés, sensiblement non antigéniques. Les conjugués préparés à partir de ces polymères et de molécules biologiquement actives telles que des protéines et des peptides présentent une durée de vie en circulation in vivo prolongée. Relativement peu de sites sur la matière active biologiquement sont utilisés en tant que sites de fixation. L'invention se rapporte également à des procédés de formation du polymère, de conjugaison des polymères avec des fractions biologiquement actives et à des procédés d'utilisation desdits conjugués.

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