Non-antigenic branched polymer conjugates

Details Non-antigenic branched polymer conjugates Non-antigenic branched polymer conjugates

C - Chemistry, Metallurgy

08

G

C08G 65/333 (2006.01) A61K 47/48 (2006.01) C07K 17/08 (2006.01) C08G 65/331 (2006.01) C12N 11/08 (2006.01) C07K 16/00 (2006.01)

Patent

CA 2174325

Branched, substantially non-antigenic polymers are disclosed. Conjugates prepared with the polymers and biologically active molecules such as proteins and peptides demonstrate extended circulating life in vivo. Substantially fewer sites on the biologically active material are used as attachment sites. Methods of forming the polymer, conjugating the polymers with biologically active moieties and methods of using the conjugates are also disclosed.

L'invention concerne des polymères ramifiés sensiblement non antigéniques. Les conjugués préparés au moyen de ces polymères et de molécules biologiquement actives, telles que des protéines et des peptides, présentent une durée de circulation <u>in vivo</u> prolongée. Un nombre sensiblement inférieur de sites sur le matériau biologiquement actif sont utilisés en tant que sites de fixation. L'invention concerne également des procédés de préparation d'un tel polymère, de combinaisons de ces polymères avec des fractions biologiquement actives, ainsi que des procédés d'utilisations de ces conjugués.

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