A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/14 (2006.01) A61K 9/16 (2006.01)
Patent
CA 2547712
The present invention provides a composition of low water solubility drug, dissolved or dispersed in a non crystalline or low crystalline form in an emulsion type composition of internal oily-solvent and external non-hydrous and water soluble solvent, whereas 1) emulsifying stabilizer comprises low fraction of the composition, and 2) emulsions of mean droplets size below one micron is obtained upon dilution with physiological fluids, and 3) facilitated dispersion of biologically active agents in body fluids is obtained, and more particularly to facilitating biological availability or improving clinical performance.
L'invention concerne une composition pour un médicament faiblement soluble dans l'eau, dissout ou dispersé sous une forme non cristalline ou faiblement cristalline dans une composition de type émulsion comprenant un solvant huileux interne et un solvant soluble aqueux et non hydrique externe, 1) un stabilisateur émulsifiant comprenant une petite fraction de la composition ; 2) des émulsions sous forme de gouttelettes sont inférieures au micron et sont obtenues par dilution de liquide physiologique ; 3) une dispersion facilitée d'agents biologiques actifs dans les fluides corporels est obtenue, ce qui permet, en particulier, de faciliter la disponibilité biologique ou l'amélioration des performances cliniques.
Borden Ladner Gervais Llp
Friedman Doron
LandOfFree
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