Non-aqueous pharmaceutical compositions

Details Non-aqueous pharmaceutical compositions Non-aqueous pharmaceutical compositions

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/08 (2006.01) A61K 31/55 (2006.01) A61K 31/5517 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01) A61K 47/22 (2006.01)

Patent

CA 2697825

The present invention provides a composition for intranasal delivery of a drug comprising: (i) the drug; and (ii) a non-aqueous vehicle comprising (a) propylene glycol and at least one additional solvent selected from N-methylpyrrolidone, propylene carbonate, dimethyl sulfoxide and at least one propylene glycol fatty acid ester; (b) from about 40 to 100 % by volume of N-methylpyrrolidone; or (c) from about 40 to 100% by volume of dimethyl sulfoxide (DMSO).

L'invention concerne une composition pour administration intranasale d'un médicament comprenant: (i) le médicament; et (ii) un excipient non aqueux comprenant (a) du propylène glycol et au moins un solvant additionnel choisi parmi N-méthylpyrrolidone, carbonate de propylène, sulfoxyde de diméthyle et au moins un ester d'acide gras de propylène glycol; (b) environ 40 à 100% en volume de N-méthylpyrrolidone; ou (c) environ 40 à 100% en volume de sulfoxyde de diméthyle (DMSO).

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