C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 241/18 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2692671
The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I, wherein, R1, R2, R3, R8, and R9 are defined herein. Additionally, the present application provides pharmaceutical compositions containing at least one compound according to Formula I and optionally at least one additional therapeutic agent. Finally, the present application provides methods for treating a patient suffering from an MCHR-1 modulated disease or disorder such as, for example, obesity, diabetes, depression or anxiety by administration of a therapeutically effective dose of a compound according to Formula I.
La présente invention concerne des composés, qui comprennent tous les stéréoisomères, solvats, promédicaments et formes acceptables de façon pharmaceutique de ceux-ci selon la formule I, R1, R2, R3, R8, et R9 étant définis dans ceux-ci. En outre, la présente invention concerne des compositions pharmaceutiques qui contiennent au moins un composé selon la formule I et facultativement au moins un agent thérapeutique supplémentaire. Enfin, la présente invention concerne des procédés pour traiter un patient qui souffre d'une maladie ou d'un trouble modulé par MCHR-1 tel que, par exemple, l'obésité, le diabète, la dépression ou l'anxiété par administration d'une dose efficace de façon thérapeutique d'un composé selon la formule I.
Ahmad Saleem
Bisaha Sharon N.
Ngu Khehyong
Stein Philip D.
Washburn William N.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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