C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 391/00 (2006.01) A61K 31/19 (2006.01) A61K 31/20 (2006.01)
Patent
CA 2226871
There are disclosed compounds of the general formula (I): alkyl-X-CH2 COOR wherein alkyl represents a saturated or unsaturated hydrocarbon of 8-26 carbon atoms, X represents a sulfur atom or a selenium atom and R is hydrogen or C1- C4 alkyl. Said compounds are used for the manufacturing of medicaments for the treatment of hyperlipidemic conditions, (arteriosclerotic disease), coronary artery disease and for reducing the concentration of lipids in blood of mammals, for inhibiting oxidative modification of LDL, and for reducing proliferation of cancer cells. Methods for preparing the compounds are also disclosed.
La présente invention se rapporte à des composés de formule générale (I) alkyle-X-CH¿2? COOR, dans laquelle alkyle représente un hydrocarbure saturé ou insaturé de 8-26 atomes de carbone, X représente un atome de soufre ou un atome de sélénium et R représente hydrogène ou alkyle C¿1?-C¿4?. Lesdits composés sont utilisés pour la fabrication de médicaments destinés au traitement des pathologies hyperlipidiques, (maladie artérioscléreuse), la maladie des artères coronaires et pour diminuer la concentration de lipides dans le sang des mammifères, pour inhiber la modification oxydative de LDL, et pour diminuer la prolifération des cellules cancéreuses. L'invention concerne également des procédés de préparation des composés.
Berge Rolf
Songstad Jon
Berge Rolf
Osler Hoskin & Harcourt Llp
Songstad Jon
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