Non-covalent immobilization of indicator molecules

Details Non-covalent immobilization of indicator molecules Non-covalent immobilization of indicator molecules

G - Physics

01

N

G01N 21/77 (2006.01) C08F 265/04 (2006.01) C08J 3/20 (2006.01) C08J 3/24 (2006.01)

Patent

CA 2563404

The invention relates to immobilization methods, in particular for immobilizing indicator molecules on supports such as sensors and to sensors having those molecules immobilized to their surface. Non-covalent immobilization of macromolecular indicator molecules on those supports via mechanical interlacing interpenetrating networks with polymers at the surface of a support and via ionic bonding via charged moieties of indicator molecules and ionic groups on the surface of the support are disclosed.

La présente invention concerne, d'une part des procédés d'immobilisation, et notamment d'immobilisation de molécules indicatrices sur des supports tels que des sondes, et d'autre part des sondes à la surface desquelles sont immobilisées ces molécules. L'invention concerne plus particulièrement l'immobilisation non-covalente de molécules indicatrices macromoléculaires sur ces supports via un entrelacement mécanique avec des polymères à la surface du support et via une liaison ionique au moyen de groupes fonctionnels chargés de molécules indicatrices, et des groupes ioniques à la surface du support.

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