Non-endogenous, constitutively activated known g...

Details Non-endogenous, constitutively activated known g... Non-endogenous, constitutively activated known g...

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) C07K 14/72 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2402392

The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is known ("known GPCRs"), and most particularly to mutated (non-endogenous) versions of the knowns GPCRs for use, most preferably in screening assays for the direct identification of candidate compounds as inverse agonists, agonists and partial agonists.

L'invention concerne des récepteurs transmembranaires, et plus précisément un récepteur couplé à la protéine G (GPCR) de type humain pour lequel le ligand endogène est connu (GPCR connu), et plus précisément encore des versions mutantes (non endogènes) de ce récepteur, de préférence dans des essais de criblage pour l'identification directe de composés candidats en tant qu'agonistes inverses, agonistes et agonistes partiels.

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