Non-enzymatic chemical amidation process

Details Non-enzymatic chemical amidation process Non-enzymatic chemical amidation process

C - Chemistry, Metallurgy

07

K

C07K 2/00 (2006.01) C07K 1/12 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C12P 21/06 (2006.01)

Patent

CA 2331330

A simple non-enzymatic method of preparing a peptide C-terminal amide is described. Such method may be applied to a variety of peptide C-terminal carboxylic acid ester substrates. A simple non-enzymatic method of preparing a peptide C-terminal amide from a fusion peptide C-terminal carboxylic acid ester is also described. Peptide C-terminal amides may be used to prepare various pharmaceutical compositions.

L'invention concerne une méthode simple non enzymatique permettant de préparer un amide peptidique C-terminal, cette méthode pouvant s'appliquer à différents substrats d'un ester d'acide carboxylique peptidique C-terminal. L'invention concerne également une méthode simple non enzymatique permettant de préparer un amide peptidique C-terminal à partir d'un ester d'acide carboxylique C-terminal d'un peptide de fusion, les amides peptidiques C-terminaux ainsi obtenus pouvant être utilisés pour préparer diverses compositions pharmaceutiques.

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