Non-food crop plant bioreactor

Details Non-food crop plant bioreactor Non-food crop plant bioreactor

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01H 5/00 (2006.01) A61K 38/20 (2006.01) C12N 5/10 (2006.01) C12N 15/00 (2006.01) C12N 15/24 (2006.01) C12N 15/82 (2006.01)

Patent

CA 2188220

A novel method for the production of transgenic proteins of interest suitable for oral administration is disclosed. The method involves the preparation of a protein of interest suitable for oral administration within a non-food crop plant comprising, transforming the non-food crop plant with a suitable vector containing a gene of interest and appropriate regulatory regions to ensure expression of the gene of interest within the non-food crop plant, such that the non-food crop plant is characterized as being non-toxic, non-addictive, palatable, and requiring minimal or no processing prior to oral administration. An example of a non-food crop plant is low nicotine tobacco. Proteins of interest may include pharmaceutically active proteins such as growth regulators, insulin, interferons, interleukins, growth hormone, erythropoietin, G-CSF, GM-CSF, hPG-CSF, M-CSF, Factor VIII, Factor IX, tPA, antibodies, antigens and combinations and/or derivatives thereof.

Nouvelle méthode pour la production de protéines transgéniques pour administration orale, consistant à préparer une protéine cible pour administration orale chez une plante cultivée non alimentaire, à transformer cette plante avec un vecteur approprié contenant un gène cible et des régions régulatrices pour permettre l'expression du gène cible à l'intérieur de la plante, de telle façon que cette dernière soit non toxique, non toxicomanogène, de goût agréable, et nécessitant un traitement minimal ou aucun traitement avant l'administration orale. Exemple de plante cultivée non alimentaire : tabac à faible teneur en nicotine. Parmi les protéines cibles, on peut citer des protéines à activité pharmaceutique, comme les régulateurs de croissance, l'insuline, les interférons, les interleukines, l'hormone de croissance, l'érythropoïétine, G-CSF, GM-CSF, hPG-CSF, M-CSF, le facteur VIII, le facteur IX, tPA, les anticorps, les antigènes, et leurs combinaisons (ou) dérivés.

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