Non-fucosylated antibodies

Details Non-fucosylated antibodies Non-fucosylated antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2682382

Provision of non-fucosylated therapeutic antibodies. More particularly non-fucosylated anti-CD20, anti-CD23 and anti-CD80 antibodies, which show enhanced antibody effector functions. Also provided are cells expressing the non-fucosylated antibodies and therapeutic methods using the non-fucosylated antibodies.

La présente invention concerne des anticorps thérapeutiques non fucosylés. Plus particulièrement, la présente invention concerne des anticorps anti-CD20, anti-CD23 et anti-CD80 non fucosylés qui présentent des fonctions effectrices de l'anticorps renforcées. L'invention concerne également des cellules exprimant les anticorps non fucosylés et des procédés thérapeutiques utilisant les anticorps non fucosylés.

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