A - Human Necessities – 01 – K
Patent
A - Human Necessities
01
K
A01K 67/027 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/00 (2006.01)
Patent
CA 2221028
A non-human mammal genetically modified without affecting its genome and having any two of the following pathological signs: (a) a blood-brain barrier that is open or permeable to water-soluble blood molecules non-specific for the cerebral parenchyma, (b) an astrocyte disorder revealed particularly by physical network disorganisation, the disappearance of perivascular feet around the capillaries, and gliosis, (c) microglial cell activation, (d) demyelinisation plates, particularly in the brain stem and/or the cerebral white matter, and (e) central nervous system glial and endothelial cell lesions, as well as the uses of said animal, are disclosed.
Animal mammifère, non humain, modifié sans affecter son génome, possédant au moins deux quelconques des signes pathologiques suivants: (a) une barrière hématoencéphalique ouverte ou perméable aux molécules hydrosolubles du sang non spécifiques du parenchyme cérébral; (b) une atteinte astrocytaire notamment révélée par la désorganisation des réseaux physiologiques, par une disparition des pieds astrocytaires autour des vaisseaux capillaires et par une gliose; (c) une activation des cellules microgliales; (d) des plaques de démyélinisation, notamment présentes dans le tronc cérébral et/ou la substance blanche cérébelleuse; (e) des lésions des cellules gliales et des cellules endothéliales du système nerveux central, et utilisations de l'animal.
Benjelloun Nabila
Perron Herve
Rieger Francois
Bio Merieux
Swabey Ogilvy Renault
LandOfFree
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