C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 41/00 (2006.01) C07H 19/06 (2006.01) C12P 7/62 (2006.01) C12P 17/16 (2006.01) C12P 19/02 (2006.01)
Patent
CA 2346702
The present invention relates to a process for the biocatalyst-mediated enantioselective conversion of enantiomeric mixtures of hydrophobic esters using a biphasic solvent system. More particularly, the present invention relates to the enzyme-mediated enantioselective synthesis of anti-viral compounds, such as 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane (FTC) and its analogues, in a non-homogeneous reaction system.
L'invention concerne un procédé de conversion énantiosélective biocatalysée de mélanges énantiomères d'esters hydrophobes à l'aide d'un système solvant biphasique. Plus particulièrement, l'invention traite de la synthèse énantiosélective enzymatique de composés antiviraux tels que le 2-hydroxyméthyl-5-(5-fluorocytosine-1-yle)-1,3-oxathiolane (FTC) et ses analogues, dans un système de réaction non homogène.
Wang Yi Fong
Yao Yiming
Altus Biologics Inc.
Altus Pharmaceuticals Inc.
Gowling Lafleur Henderson Llp
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