A - Human Necessities – 01 – K
Patent
A - Human Necessities
01
K
A01K 67/027 (2006.01) C07K 14/47 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2447276
The objects of the present invention is to provide a preventive method for the progress of neuropsychiatric disorders, a therapeutic agent for neuropsychiatric disorders, a screening method thereof, and a therapeutic method through the analysis of the mechanisms leading to neuropsychiatric disorders such as Nasu-Hakola diseases and the like. The non-human animal model of oligodendrocytes developmental disorders was generated by making the DAP12 gene function deficient on its chromosome. The DAP12 knockout mouse develops myelination disorders including hypomyelinosis in the brain, particularly in the frontal head and the thalamus, further leading to neuropsychiatric disorders such as Nasu-Hakola disease and the like with aging. The screening method for a therapeutic agent, the diagnostic method, and the therapeutic method, wherein the DAP12 knockout mouse developing these disorders are used, have been developed.
Le mécanisme provoquant des troubles psychonévrotiques, tels que la maladie de Nasu-Hakora, est analysé de manière à élaborer une méthode permettant de prévenir la progression des troubles psychonévrotiques, à élaborer des médicaments contre ces troubles psychonévrotiques, à élaborer un procédé de criblage et une méthode thérapeutique. Un modèle animal non humain du troubles du développement des oligodendrocytes est réalisé par suppression de la fonction génique DAP12 sur un chromosome. La souris knockout DAP12 souffre d'hypomyélinisation dans le cerveau (en particulier, le front et le thalamus), à savoir, des troubles de la myélinisation, parmi lesquels, l'hypomyélinisation. En vieillissant, cet animal souffre également de troubles psychonévrotiques, tels que la maladie de Nasu-Hakora. L'utilisation de la souris knockout DAP12 présentant ces troubles permet de développer un procédé de criblage, un médicament, une méthode diagnostique et une méthode thérapeutique.
Aso Hiroaki
Fujiwara Michihiro
Takai Toshiyuki
Japan Science And Technology Agency
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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