Non-human animal model unresponsive to mycoplasma derived...

A - Human Necessities – 01 – K

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Details

A01K 67/027 (2006.01) C07K 7/08 (2006.01) C07K 14/705 (2006.01) C12N 5/00 (2006.01) C12N 15/00 (2006.01) C12N 15/85 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2416949

An object of the present invention is to provide a non-human animal model unresponsive to a mycoplasma-derived lipoprotein/lipopeptide, and a method for screening an inhibitor or a promoter for a response to a mycoplasma-derived lipoprotein with the use of the non-human animal model. A non-human animal model whose function of a gene that encodes a protein such as TLR6 that specifically recognizes a mycoplasma-derived lipoprotein is deficient on its chromosome, for example, a TLR6 knockout mouse, is generated. With the use of the non-human animal model unresponsive to a mycoplasma- derived lipoprotein or an immune cell such as a macrophage derived from the non-human animal model, a subject material and a mycoplasma-derived lipoprotein, a response to a mycoplasma-derived lipoprotein in the non-human animal model or the immune cell is measured/evaluated, and then an inhibitor or a promoter for a response to that is screened.

La présente invention concerne des modèles d'animaux non humains qui ne réagissent pas à la lipoprotéine ou au lipopeptide issus de mycoplasma, et une technique d'analyse d'un inhibiteur ou d'un promoteur de réponse à une lipoprotéine issue de mycoplasma par l'utilisation de ces modèles d'animaux non humains. On construit un modèle d'animal non humain (par exemple, une souris knock out TLR6) présentant la délétion de la fonction du gène codant pour une protéine qui reconnaît spécifiquement une lipoprotéine issue de mycoplasma telle que TLR6 sur son chromosome. En utilisant ce modèle d'animal non humain qui ne réagit pas à la lipoprotéine issue de mycoplasma ou à des immunocytes (macrophages, etc.) issus de ces modèles, une substance d'essai et cette lipoprotéine issue de mycoplasma, on analyse et on évalue la réponse à cette lipoprotéine issue de mycoplasma dans ce modèle ou ces immunocytes susmentionnés, ce qui permet d'analyser un inhibiteur ou un promoteur de la réponse à cette lipoprotéine.

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