Non-human carbonyl hydrolase mutants, dna sequences and...

C - Chemistry – Metallurgy – 12 – N

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195/39, 195/1.22

C12N 9/48 (2006.01) C12N 5/10 (2006.01) C12N 15/52 (2006.01) C12N 15/57 (2006.01) C12N 15/63 (2006.01)

Patent

CA 1341280

Novel carbonyl hydrolase mutants derived from the amino acid sequence of naturally-occurring or recombinant non-human carbonyl hydrolases and DNA sequences encoding the same. The mutant carbonyl hydrolases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant carbonyl hydrolase to encode the substitution, insertion or deletion of one or more amino acids in the amino acid sequence of a precursor carbonyl hydrolase. Such mutants have one or more properties which are different than the same property of the precursor hydrolase.

536058

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