Non-human mammals for the production of chimeric antibodies

Details Non-human mammals for the production of chimeric antibodies Non-human mammals for the production of chimeric antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2739038

The invention provides knock-in non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing knock-in cells and mammals. Certain aspects of the invention include chimeric antibodies, humanized antibodies, pharmaceutical compositions and kits. Certain aspects of the invention also relate to diagnostic and treatment methods using the antibodies of the invention.

La présente invention concerne des cellules et des mammifères knock-in non humains possédant un génome qui code des anticorps chimériques. L'invention porte aussi sur des méthodes permettant de produire des cellules et des mammifères knock-in. Certains aspects de linvention ont trait aux anticorps chimériques, aux anticorps humanisés ainsi quaux compositions et kits pharmaceutiques. Dautres aspects de linvention se rapportent, en outre, aux méthodes de diagnostic et de traitement utilisant les anticorps de linvention.

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