A - Human Necessities – 01 – K
Patent
A - Human Necessities
01
K
A01K 67/027 (2006.01) C07K 16/22 (2006.01) C07K 16/46 (2006.01)
Patent
CA 2565068
A non human transgenic animal able to express ubiquitarily an anti-NGF neutralizing antibody wherein said antibody is composed by an endogenous VH chain and by an exogenous VK chain; uses as an animal model to identify compounds with therapeutic activity, in particular for neurodegenerative pathologies. Method for the early prognosis and/or diagnosis of neurodegenerative diseases comprising the drawing of a peripheral biological fluid from a patient and the detection in said fluid of antibodies anti-NGF, or anti-TrkA or antibodies against proteins linked to NGF activity.
L'invention concerne un animal transgénique non humain capable d'exprimer de manière ubiquitaireun anticorps neutralisant un anti-NGF, ledit anticorps étant composé d'une chaîne endogène VH et d'une chaîne exogène VK; des utilisations dudit animal en tant que modèle pour l'identification de composés possédant une activité thérapeutique, en particulier pour les pathologies neurodégénératives. L'invention concerne une méthode de pronostic et/ou de diagnostic précoce de maladies neurodégénératives, consistant à prélever un liquide organique périphérique chez un patient et à détecter dans ce liquide des anticorps anti-NGF, ou anti-TrkA, ou bien des anticorps dirigés contre des protéines liées à un activité NGF.
Capsoni Simona
Cattaneo Antonino
Dennison Associates
Lay Line Genomics S.p.a.
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