C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/00 (2006.01) A01K 67/027 (2006.01) C07K 14/62 (2006.01) C12N 5/10 (2006.01) C12N 15/17 (2006.01) C12N 15/37 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2284833
The invention concerns the use of a non-human transgenic mammal wherein at least one of the alleles of at least one of two genes coding for endogenous insulin is made functionally inoperative with respect to the expression of insulin for determining medicines acting on pathologies involving insulin.
L'invention concerne l'utilisation d'un animal mammifère transgénique non humain dans lequel l'un au moins des allèles de l'un au moins des deux gènes codant pour l'insuline endogène est rendu fonctionnellement inopérant vis-à- vis de l'expression de l'insuline pour la détermination de médicaments actifs, sur des pathologies impliquant l'insuline.
Bucchini Danielle
Jami Jacques
Joshi Rajiv Lochan
Fetherstonhaugh & Co.
Inserm (institut de La Sante Et de La Recherche Medicale)
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