C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) A61P 3/06 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2360103
The present invention relates to a transgenic non-human mammal whose germ cells and somatic cells contain a knockout mutation in DNA encoding orphan nuclear receptor ERR.alpha.. More specifically, the invention relates to knockout mice whose germ cells and somatic cells contain a knockout mutation in DNA encoding orphan nuclear receptor ERR.alpha.. The invention further relates to such knockout non-human mammals which express an ERR.alpha. gene which is different from the endogenous gene which was disrupted. In a particular embodiment, the invention relates to a transgenic mouse having its endogenous ERR.alpha. gene disrupted and expressing human ERR.alpha.. As well, the invention relates to cell lines in which ERR.alpha. activity (and/or level) has been inactivated or augmented. The invention further relates to uses and methods of the transgenic animals of the present invention to select agents which modulate the expression and/or activity of ERR.alpha., in particular in relation to fatty acid metabolism.
L'invention concerne un mammifère transgénique non-humain dont les cellules germinales et somatiques contiennent une mutation knockout dans l'ADN codant le récepteur nucléaire orphelin ERR.alpha.. L'invention porte, plus spécifiquement, sur une souris knock-out dont les cellules germinales et somatiques contiennent une mutation knock-out dans l'ADN codant le récepteur nucléaire orphelin ERR.alpha.. L'invention se rapporte encore à des mammifères transgéniques non-humains qui expriment un gène ERR.alpha. qui diffère du gène endogène ayant été interrompu. Dans un mode de réalisation particulier, l'invention concerne une souris transgénique dont le gène ERR.alpha. endogène est interrompu et exprime le ERR.alpha. humain. Elle se rapporte à des lignées cellulaires dans lesquelles l'activité de ERR.alpha. (et/ou le niveau) a été inactivée ou augmentée ainsi qu'aux utilisations et aux procédés relatifs aux animaux transgéniques pour la sélection d'agents modulant l'expression et/ou l'activité de ERR.alpha..
Giguere Vincent
Luo Jiang-Ming
Sladek Robert
Giguere Vincent
Goudreau Gage Dubuc
Luo Jiang-Ming
University Mcgill
LandOfFree
Non-human transgenic animal whose germ cells and somatic... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Non-human transgenic animal whose germ cells and somatic..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Non-human transgenic animal whose germ cells and somatic... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1349998