Non-human transgenic animals expressing humanised antibodies...

Details Non-human transgenic animals expressing humanised antibodies... Non-human transgenic animals expressing humanised antibodies...

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A01K 67/027 (2006.01) C07K 16/00 (2006.01)

Patent

CA 2747534

A non-human mammal containing an endogenous lambda light chain gene locus, an endogenous kappa light chain gene locus and an endogenous heavy chain gene locus, each of which can re- arrange so that immunoglobulin heavy and light chain genes are formed and expressed in B-cells following antigen challenge but said loci have been mutated so that the ability to form functional immunoglobulin tetramers comprising re-arranged heavy and light chains produced from said mutated loci has been substantially reduced or eliminated.

L'invention concerne un mammifère non humain présentant un locus de gène de chaînes légères lambda endogènes, un locus de gène de chaînes légères kappa endogènes et un locus de gène de chaînes lourdes endogènes, chaque locus pouvant être réagencé de sorte que les gènes de chaînes lourdes et légères d'immunoglobuline soient formés et exprimés dans les lymphocytes B suite à une provocation antigénique. Cependant, ces loci ont été soumis à une mutation, de sorte que la capacité à former des tétramères d'immunoglobuline fonctionnelle comprenant des chaînes lourdes et légères réagencées produites par les loci mutants soit sensiblement réduite ou supprimée.

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