Non-human transgenic mammals used as models for human...

Details Non-human transgenic mammals used as models for human... Non-human transgenic mammals used as models for human...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 49/00 (2006.01) C07K 14/82 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2466372

The invention relates to non-human transgenic mammals which reproduce human pathologies originating from stem cells, e.g. chromosomal anomalies associated with chronic myeloid leukaemia, B-cell lineage acute lymphoblastic leukaemia, T-cell lineage acute lymphoblastic leukaemia, or the migration of hematopoietic or embryonic stem cells. The invention makes use of the expression of the genes involved in said pathology in human beings, employing a promoter which directs the expression of a transgene in cells Sca-1+. The aforementioned transgenic animals form a model which is used to study the above-mentioned diseases and to evaluate compounds for treating and/or preventing said diseases.

L'invention se rapporte à des mammifères non humains transgéniques reproduisant les pathologies humaines ayant des cellules souches pour origine, telles que, par exemple, des anomalies chromosomiques associées à une leucémie myéloïde chronique, à une leucémie lymphoblastique aiguë de lignée B, à une leucémie lymphoblastique aiguë de lignée T, ou à la migration de cellules souches hématopoïétiques ou embryonnaires. L'expression des gènes impliqués dans ladite pathologie chez des êtres humains est utilisée au moyen d'un promoteur qui dirige l'expression d'un transgène dans des cellules Sca-1+. Lesdits animaux transgéniques constituent un modèle pour l'étude desdites maladies et pour l'évaluation de composés utiles pour le traitement et/ou la prévention desdites maladies.

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