C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 217/58 (2006.01) A61K 31/131 (2006.01) A61K 31/395 (2006.01) A61P 3/00 (2006.01) A61P 25/00 (2006.01) C07C 217/20 (2006.01) C07C 217/74 (2006.01) C07C 233/73 (2006.01) C07C 237/08 (2006.01) C07C 237/32 (2006.01) C07C 271/24 (2006.01) C07C 271/34 (2006.01) C07C 311/05 (2006.01) C07C 311/09 (2006.01) C07C 311/11 (2006.01) C07C 311/13 (2006.01) C07C 311/17 (2006.01) C07C 311/18 (2006.01) C07C 323/62 (2006.01) C07C 409/12 (2006.01) C07D 207/00 (2006.01) C07D 207/09 (2006.01) C07D 207/14 (2006.01) C07D 207/
Patent
CA 2441080
The present invention discloses novel substituted aryl alkylamine compounds of Formula (I) or pharmaceutically acceptable salts thereofwhich have selective histamine-H3 receptor antagonist activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such cyclic amines as well as methods of using them to treat obesity and other histamine H3 receptor -related diseases.
L'invention concerne de nouveaux composés d'aryl alkylamine substitués représentés par la formule (I), ou des sels pharmaceutiquement acceptables de ceux-ci, qui possèdent une activité sélective d'antagoniste des récepteurs H3 de l'histamine, ainsi que des procédés de préparation de ces composés. Dans une autre forme de réalisation, l'invention concerne des compositions pharmaceutiques contenant de telles amines cycliques, ainsi que des procédés d'utilisation de celles-ci pour traiter l'obésité et d'autres maladies associées aux récepteurs H3 de l'histamine.
Beavers Lisa Selsam
Gadski Robert Alan
Hipskind Philip Arthur
Lindsley Craig William
Lobb Karen Lynn
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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