Non-immunogenic prodrugs and selectable markers for use in...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/86 (2006.01) A61K 38/20 (2006.01) A61K 38/27 (2006.01) A61K 38/37 (2006.01) A61K 38/44 (2006.01) A61K 48/00 (2006.01) C07K 14/755 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2277944

The present invention provides methods for delivering a gene delivery vehicle to a warm-blooded animal, comprising the step of administering to a warm- blooded animal a gene delivery vehicle which directs the expression of a non- immunogenic selectable marker. Within other aspects, methods are provided for delivering a gene delivery vehicle to a warm-blooded animal, comprising the step of administering to a warm-blooded animal a gene delivery vehicle which directs the expression of a non-immunogenic molecule which is capable of activating an otherwise inactive compound into an active compound.

La présente invention concerne des méthodes de fourniture d'un véhicule de fourniture de gènes à un homéotherme, la méthode consistant à administrer à un homéotherme un véhicule de fourniture de gènes dirigeant l'expression d'un marqueur non immunogène capable d'être sélectionné. D'autres aspects de l'invention concernent des méthodes de fourniture d'un véhicule de fourniture de gènes à un homéotherme, les méthodes consistant à administrer à un homéotherme, un véhicule de fourniture de gènes dirigeant l'expression d'une molécule non immunogène capable d'activer un composé par ailleurs inactif, en un composé actif.

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