Non-infectious hiv particles and uses therefor

Details Non-infectious hiv particles and uses therefor Non-infectious hiv particles and uses therefor

C - Chemistry, Metallurgy

12

N

C12N 15/49 (2006.01) A61K 39/21 (2006.01) C07K 14/16 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 7/04 (2006.01) C12N 15/867 (2006.01) C12Q 1/70 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2117884

2117884 9320220 PCTABS00027 This invention related to constructs comprising mutant HIV genomes having an alteration in a nucleotide sequence which is critical for genomic RNA packaging and non-infectious, immunogenic HIV particles produced by expression of these constructs in mammalian cells. Cell lines which stably produce non-infectious, immunogenic HIV particles are also included. Prophylactic and therapeutic vaccines, diagnostic reagents, and related methods are further described.

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