C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/867 (2006.01) A61K 35/76 (2006.01) A61K 39/21 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01)
Patent
CA 2579753
The invention concerns a non-integrative and non-replicative recombinant lentivirus as well as its uses, in particular for preparing a composition for transferring genes in vitro, ex vivo or in vivo. The invention is useful for transferring genes in any mammal organism, for example in liver, muscle, pancreas or central nervous system (including the ocular sphere) tissues or cells, and in particular for treating disorders or pathologies such as, for example, central nervous system, including the ocular sphere, disorders.
La présente invention décrit un lentivirus recombinant non intégratif et non réplicatif ainsi que ses utilisations, notamment pour la préparation d~une composition destinée au transfert de gènes in vitro, ex vivo ou in vivo. L~invention est utilisable pour le transfert de gènes dans tout organisme mammifère, par exemple dans les tissus ou cellules du foie, muscle, pancréas et du système nerveux central (y compris de la sphère oculaire), et notamment pour le traitement de désordres et pathologies tels que par exemple des désordres du système nerveux central, y compris de la sphère oculaire.
Mallet Jacques
Philippe Stephanie
Sarkis Chamsy
Serguera Che
Centre National de La Recherche Scientifique
Robic
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