Non-invasive detection of endothelial dysfunction by blood...

A - Human Necessities – 61 – B

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A61B 5/0275 (2006.01) A61B 5/022 (2006.01)

Patent

CA 2413352

Endothelial dysfunction is a known indicator of cornary artery disease. Endothelial dysfunction is detected by measuring tracer presence in arteries following the release of blood flow into the limb after a period of blockage of blood flow into the limb. The blood flow is measured in a pair of laterally opposed limbs, such as the patient's forearms, and the tracer presence is compared between both limbs. An efficient tracer is a radionuclide and the non- invasive measurement of the radionuclide is carried out by gamma ray detection.

Une dysfonction endothéliale constitue un indicateur connu de maladie des artères coronaires. Selon l'invention, on détecte cette dysfonction endothéliale en mesurant la présence d'un marqueur dans les artères, aussitôt après avoir libéré le flux sanguin dans un membre et ce après une période de blocage de ce flux dans le membre. On mesure le flux sanguin dans une paire de membres opposés latéralement, tels que les avant-bras d'un patient, et on compare la présence du marqueur dans les deux membres. Un marqueur efficace est un radionucléide et la mesure non vulnérante de ce radionucléide s'effectue par le biais d'une détection de rayons gamma.

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