C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/54 (2006.01) A61B 6/00 (2006.01) A61K 51/04 (2006.01) C07F 9/58 (2006.01)
Patent
CA 2474142
The invention provides a series of lipophilic phosphonium cations (PhCs) labeled with 18F for non-invasive assessment of .DELTA..PSI.m, lipophilic ammonium cation analogs of the PhCs, and methods of using same for imaging and detection of mitochondrial-related pathologies in patients using PET or SPECT.
L'invention concerne une série de cations de phosphonium liphophiles (PhCs) marqués au ?18¿F en vue d'assurer une évaluation non-invasive de ??m. L'invention a pour objet des analogues de cations d'ammonium lipophiles de PhCs. En outre, l'invention traite de procédés d'utilisation de ces derniers pour imager et détecter des pathologies liées aux mitochondries chez des patients, par TEP ou TEMP.
Dannals Robert
Frost James J.
Madar Igal
Ravert Hayden T.
Scheffel Ursula A.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
The Johns Hopkins University
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