Non-invasive fetal rhd genotyping from maternal whole blood

Details Non-invasive fetal rhd genotyping from maternal whole blood Non-invasive fetal rhd genotyping from maternal whole blood

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2731086

The present invention discloses methods of determining the RhD genotype of subject. In particular, the invention provides a non-invasive method of determining fetal RhD genotype from a maternal biological sample containing fetal cells. The invention also provides novel probes and primers useful in the described methods. Kits and mixtures comprising the novel probes and primers are also disclosed.

La présente invention concerne des procédés de détermination du génotype RHD d'un sujet. L'invention concerne en particulier un procédé non invasif de détermination du génotype RHD ftal à partir d'un échantillon biologique maternel contenant des cellules ftales. L'invention fournit en outre de nouvelles sondes et amorces utiles dans les procédés décrits. Des kits et des mélanges comprenant les nouvelles sondes et amorces sont également décrits.

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