Non-invasive intravascular thrombolysis using modified...

Details Non-invasive intravascular thrombolysis using modified... Non-invasive intravascular thrombolysis using modified...

A - Human Necessities

61

K

A61K 41/00 (2006.01) A61B 17/22 (2006.01) A61K 31/727 (2006.01) A61K 38/49 (2006.01) A61P 7/02 (2006.01) A61K 9/127 (2006.01) A61K 49/00 (2006.01)

Patent

CA 2529304

A non-invasive method for disrupting a blood clot within the vasculature of a patient using new ultrasound techniques is provided. Lipid vesicles containing a gas or gaseous precursor are administered intravascularly to the patient and ultrasound having a power greater than about 0.5 Watts/cm2 to about 20 Watts/cm2 for about 10% to about 80% of the duty cycle is applied to the patient for a period of time sufficient to induce rupture of the vesicles adjacent to the site of the blood clot, thereby disrupting the blood clot. Administration of thrombolytic biological agents is not required. Optionally, progress of clot disruption can be monitored using magnetic resonance imaging.

L'invention concerne une méthode non invasive de désagrégation d'un caillot sanguin dans le système vasculaire d'un patient au moyen de nouvelles techniques à ultrasons. Des vésicules lipidiques contenant un gaz ou un précurseur gazeux sont administrées par voie intravasculaire au patient et un ultrason, dont la puissance est supérieure à environ 0,5 à 20 Watts/cm?2¿ pendant environ 10 à 80 % du cycle de travail, est appliqué sur le patient pendant une durée suffisante pour occasionner la rupture des vésicules adjacentes à l'emplacement du caillot sanguin, ce qui a pour effet de désagréger ce dernier. L'administration de substances biologiques thrombolytiques n'est pas requise. Facultativement, la progression de la désagrégation du caillot peut être contrôlée par imagerie par résonance magnétique.

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