Non-invasive methods of using spectral information in...

A - Human Necessities – 61 – B

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A61B 5/1455 (2006.01) A61B 5/00 (2006.01) G01N 21/65 (2006.01)

Patent

CA 2661952

A non-invasive method of determining the concentration of an analyte uses Raman or fluorescence spectral information. A high-intensity band of light is applied to one side of skin tissue. The high-intensity light enters the skin tissue and generates a Raman or fluorescence signal. A Raman-generating material or fluorescence-generating material is placed in a location nearest the other side of skin tissue. The Raman-generating or fluorescence- generating material is located generally opposite of the entry of the applied high-intensity light. The Raman or fluorescence signal is collected and the analyte concentration is determined using the collected Raman signal.

L'invention concerne un procédé non invasif pour la détermination de la concentration d'un analyte à l'aide d'informations spectrales Raman ou de fluorescence. Une bande de lumière de haute intensité est appliquée sur un côté du tissu de la peau. La lumière de haute intensité pénètre dans le tissu cutané et génère un signal Raman ou de fluorescence. Une matière de génération de Raman ou une matière de génération de fluorescence est placée à un endroit aussi proche que possible, de l'autre côté du tissu cutané. La matière de génération de Raman ou de fluorescence est située en général à l'opposé de l'entrée de la lumière de haute intensité appliquée. Le signal Raman ou de fluorescence est recueilli et la concentration d'analyte est déterminée à l'aide du signal Raman collecté.

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