Non-ionic polyol contrast media from ionic contrast media

Details Non-ionic polyol contrast media from ionic contrast media Non-ionic polyol contrast media from ionic contrast media

C - Chemistry, Metallurgy

07

C

167/36, 260/550.

C07C 237/46 (2006.01) A61K 49/04 (2006.01) C07C 233/00 (2006.01) C07C 233/16 (2006.01)

Patent

CA 1339666

Novel non-ionic contrast media are efficiently prepared from generally available ionic contrast media or non-iodinated precursors. Particularly, polyhydroxyhalo-hydrocarbons are employed with a triiodo-substituted acylamido benzoic acids in aqueous weakly basic media to selectively substitute the amido nitrogen, followed by activation of the carboxyl group for amide formation.

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