A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/127 (2006.01)
Patent
CA 2554051
The presene invention relates to particulate compositions comprising at least 50% of dioleoyl phosphatidyl ethanolamine (DOPE) and 1 to 50% of Polysorbate 80 (P80). All parts are by weight relative to the sum of the weights of a+b and the compositions comprise non-lamellar particles or form non-lamellar particles when contacted with an aqueous fluid. The compositions have advantegeous stability and low toxicity and the invention also relates to pharmaceutical compositions thereof.
L'invention concerne des compositions particulaires comprenant au moins 50 % de dioléoylphosphatidyléthanolamine (DOPE) et entre 1 et 50 % de polysorbate 80 (P80). Toutes les parties sont des parties en poids, déterminées par rapport au total des parties en poids (a+b), et les compositions selon l'invention comportent des particules non lamellaires ou permettent la formation de particules non lamellaires lorsqu'elles sont mises en contact avec un fluide aqueux. Lesdites compositions présentent une stabilité avantageuse et une faible toxicité. Cette invention se rapporte en outre à des compositions pharmaceutiques correspondantes.
Barauskas Justas
Tiberg Fredrik
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Camurus Ab
LandOfFree
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