Non-m non-o hiv strains, fragments and applications

Details Non-m non-o hiv strains, fragments and applications Non-m non-o hiv strains, fragments and applications

C - Chemistry, Metallurgy

12

N

C12N 15/49 (2006.01) A61K 39/21 (2006.01) C07K 14/16 (2006.01) C07K 16/10 (2006.01) C12N 7/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2274490

The invention concerns retroviral strains of the group HIV-1, non-M non-O, particularly a strain called YBF30, its fragments and its applications as diagnosis reagent and as immunogenic agent. The HIV-2 different both from the group M and from the group O have the following characteristics: little or no serological response with respect to proteins of groups M and O and strong serological response with respect to proteins derived from the YBF30 strain or the SIV CPZGAB strain; absence of genomic amplification by the primers of regions env and gag of the HIV-1-1 of groups M and O; genomic amplification in the presence of the primers derived from the YBF30 strain; and homology of the envelope gene products higher than 70 % with respect to the YBF30 strain.

Souches de rétrovirus du groupe VIH-1, non-M non-O, notamment une souche dénommée YBF30, ses fragments ainsi que ses applications, en tant que réactif de diagnostic et en tant qu'agent immunogène. Les VIH-1 distincts à la fois du groupe M et du groupe O présentent les caractéristiques suivantes: peu ou pas de réactivité sérologique vis-à-vis des protéines des groupes M et O et forte réactivité sérologique vis-à-vis des protéines issues de la souche YBF30 selon l'invention ou de la souche SIV CPZGAB; absence d'amplification génomique à l'aide des amorces des régions env et gag des VIH-1 des groupes M et O; amplification génomique en présence des amorces issues de la souche YBF30, selon l'invention; et homologie des produits du gène d'enveloppe supérieure à 70 % vis-à-vis de la souche YBF30.

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