Non-natural amino acid replication-dependent microorganisms...

Details Non-natural amino acid replication-dependent microorganisms... Non-natural amino acid replication-dependent microorganisms...

C - Chemistry, Metallurgy

12

N

C12N 1/20 (2006.01) A61K 39/00 (2006.01) C12N 1/21 (2006.01) C12N 15/00 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2738033

Compositions and methods of producing vaccines, including methods wherein whole organism vaccines are provided with limited replication abilities, thereby increasing vaccine safety and efficacy, through the use of non-natural, unnatural, or non-naturally encoded amino acids.

La présente invention concerne des compositions et des procédés de production de vaccins, y compris des procédés permettant de produire des vaccins à base d'organismes entiers dont les capacités de réplication sont limitées, ce qui permet daugmenter la vaccinovigilance et l'efficacité du vaccin, par l'utilisation d'acides aminés non naturels, anormaux ou encodés non naturellement.

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