Non-natural amino acids and neurotensin analogues thereof

Details Non-natural amino acids and neurotensin analogues thereof Non-natural amino acids and neurotensin analogues thereof

A - Human Necessities

61

K

A61K 38/16 (2006.01) A61K 38/08 (2006.01) C07C 229/02 (2006.01) C07D 233/44 (2006.01) C07K 7/06 (2006.01) C12Q 1/00 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2633224

This invention relates to non-natural desamino amino acid compounds, methods of making, and peptides containing these compounds as their N-terminus moieties. A preferred example is neurotensin (8-13) in which the N terminus is an alpha desamino N,N dimethyl homolysine residue.

La présente invention concerne des composés d'acides aminés désaminés, des procédés de fabrication et des peptides contenant ces composés en tant que leurs groupes fonctionnels N-terminaux. Un exemple préféré est la neurotensine (8-13) dans laquelle la terminaison N est un résidu d'alpha-desamino-N,N diméthyl-homolysine.

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