Non-nucleoside reverse transcriptase inhibitors

Details Non-nucleoside reverse transcriptase inhibitors Non-nucleoside reverse transcriptase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/41 (2006.01) A61K 31/4439 (2006.01) A61K 31/454 (2006.01) A61K 31/4709 (2006.01) A61K 31/495 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) A61P 31/18 (2006.01) C07D 249/04 (2006.01) C07D 249/10 (2006.01) C07D 257/04 (2006.01) C07D 277/36 (2006.01) C07D 285/06 (2006.01)

Patent

CA 2555633

The invention relates to compounds of formula (I) wherein Ar, X, R1, R2, R3 and R4 are as defined herein and pharmaceutical compositions thereof useful, either alone or in combination with other therapeutic agents as reverse transcriptase inhibitors against wild type and single or double mutant strains of HIV for the treatment or prophylaxis of HIV infection.

L~invention concerne les composés de formule (I) dans lesquels Ar, X, R?1¿, R?2¿, R?3¿ et R?4¿ sont tels que définis dans le présent document et les compositions pharmaceutiques de ces composés utiles, soit seules, soit en combinaison avec d~autres agents thérapeutiques en tant qu~inhibiteurs de la transcriptase inverse contre les souches de type sauvage à simple ou à double mutations du VIH en vue du traitement et de la prophylaxie de l~infection par le VIH.

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